The anti-dsDNA (double-stranded DNA) ELISA is a blood test used to detect antibodies that mistakenly target the body's own DNA. Elevated levels of these antibodies are strongly associated with systemic lupus erythematosus (SLE), an autoimmune disease. The test involves coating a plate with dsDNA, adding the patient's blood sample, and detecting any bound antibodies using an enzyme-linked reaction. A positive result can aid in the diagnosis of SLE and help monitor disease activity.

An anti-nuclear antibody (ANA) profile is a blood test that detects antibodies produced by the immune system that mistakenly target the bodys own cell nuclei.Elevated ANA levels can indicate the presence of an autoimmune disease, such as systemic lupus erythematosus (SLE), rheumatoid arthritis, or Sjogrens syndrome. The test measures both the presence and pattern of ANA, with different patterns associated with specific autoimmune conditions. A positive ANA test often requires further evaluation to confirm a diagnosis.