VGKC ANTIBODY HAVE BEEN DETECTED IN PERIPHERAL NERVOUS SYSTEM DISEASE SPECIFICALLY ASSOCIATED WITH THE CLINICAL SPECTRUM OF ACQUIRED NEUROMYOTONIA (NMT) AND CRAMP-FASCICULATION SYNDROME (CFS), AND DISORDERS OF THE CENTRAL NERVOUS SYSTEM, INCLUDING MORVAN SYNDROME, EPILEPSY AND LIMBIC ENCEPHALITIS (LE).

IGA CONSTITUTES 15% OF GAMMA GLOBULINS IN NORMAL SERUM. DECREASED LEVELS ARE SEEN IN PATIENTS WITH CONGENITAL DEFICIENCIES. MONOCLONAL ELEVATION OF IGA IS SEEN IN MULTIPLE MYELOMA & PRIMARY SYSTEMIC AMYLOIDOSIS. THIS ASSAY IS USEFUL FOR DETECTION AND MONITORING OF MONOCLONAL GAMMOPATHIES AND PRIMARY OR SECONDARY IMMUNE DEFICIENCIES.

HTTG-DGP SCREEN IS A SENSITIVE AND SPECIFIC SCREENING TEST FOR CELIAC DISEASE. THIS TEST PERFORMS SIMULTANEOUS DETECTION OF BOTH IGA & IGG ANTIBODIES TO A SELECTIVELY DEAMIDATED SYNTHETIC PEPTIDE (DGP) AND HUMAN TTG. EVEN WITH CO-EXISTENT IGA DEFICIENCY, CELIAC DISEASE CAN BE DETECTED.