CARCINOID TUMOR PANEL

160 Ratings

Rs 13,300 Rs 10,000

25 % OFF

CARCINOID ARE NEUROECTODERMAL TUMORS OF THE GASTROINTESTINAL TRACT AND PANCREAS. CARCINOID TUMORS ARE TRADITIONALLY CLASSIFIED INTO FOREGUT CARCINOIDS, MIDGUT CARCINOIDS AND HINDGUT CARCINOIDS. THE CLINICAL MANIFESTATION OF CARCINOID TUMORS ARE EXTREMELY VARIED AND OFTEN OBSCURE. THESE VARIABLE PRESENTATIONS OFTEN LEAD TO DELAY IN CORRECT DIAGNOSIS. MIDGUT CARCINOIDS RELEASE LARGE QUANTITY OF SEROTONIN (5-HYDROXYTRYPTAMIN; 5-HT) INTO CIRCULATION. HOWEVER TUMORS DERIVED FROM FOREGUT PRIMARILY SECRETE 5-HYDROXYTRYPTOPHAN (5-HTP) AND HISTAMIN. PRIMARY HINDGUT CARCINOIDS SHOW NO 5-HT OR 5-HTP SECRETORY ACTIVITY. IN CONTRAST, CHROMOGRANIN A LEVELS ARE ELEVATED IN ALMOST ALL HINDGUT TUMORS.

Included Tests

CHROMOGRANIN A IS THE FIRST LINE TEST FOR DIAGNOSING CARCINOID TUMORS. IT IS USED AS A FOLLOWUP TEST FOR TREATED CASES OF CARCINOID TUMORS. IT IS USEFUL AS AN ADJUNCT IN THE DIAGNOSIS OF OTHER NEUROENDOCRINE TUMORS INCLUDING PHEOCHROMOCYTOMA, PITUITARY ADENOMAS AND FUNCTIONING & NON-FUNCTIONING ISLET CELL AND GASTROINTESTINAL APUD TUMORS.

5-HIAA IS A MAJOR METABOLITE OF SEROTONIN EXCRETED IN URINE. NORMALLY 1-3% OF DIETARY TRYPTOPHAN IS METABOLIZED TO SEROTONIN BUT IN PATIENTS WITH INTESTINAL CARCINOID SYNDROME, AS MUCH AS 60% TRYPTOPHAN IS CONVERTED TO SEROTONIN.

SEROTONIN (5-HYDROXYTRYPTAMINE; 5-HT) IS ONE OF THE MOST THOROUGHLY CHARACTERIZED BIOLOGICALLY ACTIVE SUBSTANCE RELEASED BY CARCINOID TUMORS. CARCINOIDS ARE NEUROECTODERMAL TUMORS OF THE GASTROINTESTINAL TRACT AND PANCREAS. MIDGUT CARCINOIDS RELEASE LARGE QUANTITY OF SEROTONIN INTO CIRCULATION; HOWEVER TUMORS DERIVED FROM FOREGUT AND HINDGUT MAY PRODUCE RELATIVELY SMALL AMOUNT OF SEROTONIN.

3 ML (2 ML MIN.) SERUM FROM 1 SST AND 2 ML (1 ML MIN.) PLASMA FROM 1 LAVENDER TOP (EDTA) TUBE AND 50 ML (10 ML MIN.) ALIQUOT OF 24-HOUR URINE. COLLECT URINE WITH APPROPRIATE VOLUME OF 50% HCL TO MAINTAIN PH BETWEEN 1 2. DO NOT USE CONCENTRATED HCL. RECORD 24 HOUR VOLUME ON TEST REQUEST FORM AND URINE CONTAINER. SHIP FROZEN. PROTON PUMP INHIBITOR MEDICATIONS SHOULD BE DISCONTINUED FOR AT LEAST 2 WEEKS PRIOR TO SAMPLE COLLECTION. PATIENT SHOULD STRICTLY AVOID BANANA, KIWI, WALNUT, AVOCADO, BRINJAL, PINEAPPLE, PLUM, TOMATO & DRUGS LIKE FLUOROURACIL, MELPHALAN, PARACETAMOL & ACETAMINOPHEN, HEPARIN, L-DOPA, RESERPINE, SALICYLATES, CHLORPROMAZINE, IMIPRAMINE, ISONIAZID, MAO INHIBITORS, PHENOTHIAZINES, PROMETHAZINE, ALCOHOLIC BEVERAGES, CAFFEINE, TEA/COFFEE, TOBACCO AND STRENUOUS EXERCISE AT LEAST 72 HRS BEFORE AND DURING SPECIMEN COLLECTION.

PROTON PUMP INHIBITOR MEDICATIONS SHOULD BE DISCONTINUED FOR AT LEAST 2 WEEKS PRIOR TO SAMPLE COLLECTION. PATIENT SHOULD STRICTLY AVOID BANANA, KIWI, WALNUT, AVOCADO, BRINJAL, PINEAPPLE, PLUM, TOMATO & DRUGS LIKE FLUOROURACIL, MELPHALAN, PARACETAMOL & ACETAMINOPHEN, HEPARIN, L-DOPA, RESERPINE, SALICYLATES, CHLORPROMAZINE, IMIPRAMINE, ISONIAZID, MAO INHIBITORS, PHENOTHIAZINES, PROMETHAZINE, ALCOHOLIC BEVERAGES, CAFFEINE, TEA/COFFEE, TOBACCO AND STRENUOUS EXERCISE AT LEAST 72 HRS BEFORE AND DURING SPECIMEN COLLECTION.

CARCINOID TUMOR PANEL

Rs 13,300 Rs 10,000

25 % OFF

Included Tests

CHROMOGRANIN A; CGA

5-HIAA (5-HYDROXY INDOLE ACETIC ACID), 24 HOUR URINE

SEROTONIN (5-HT), SERUM

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