COAGULATION PROFILE BASIC
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Included Tests
THE PTT, OR APTT, IS A LABORATORY TEST USED TO MEASURE HOW LONG IT TAKES BLOOD TO CLOT. IT IS PRIMARILY USED TO EVALUATE THE INTRINSIC PATHWAY OF BLOOD COAGULATION, WHICH INVOLVES SEVERAL CLOTTING FACTORS. AN ABNORMAL PTT RESULT CAN INDICATE A DEFICIENCY OR DYSFUNCTION OF ONE OR MORE OF THESE CLOTTING FACTORS, LEADING TO BLEEDING OR CLOTTING DISORDERS. THE PTT TEST IS COMMONLY USED TO MONITOR ANTICOAGULANT THERAPY, SUCH AS HEPARIN OR LOW-MOLECULAR-WEIGHT HEPARIN, WHICH WORK BY PROLONGING THE CLOTTING TIME.
THROMBIN TIME (TT) IS A BLOOD TEST THAT MEASURES HOW LONG IT TAKES FOR BLOOD TO CLOT AFTER ADDING THROMBIN, AN ENZYME CRUCIAL FOR CLOTTING. IT ASSESSES FIBRINOGEN FUNCTION, A KEY CLOTTING PROTEIN. PROLONGED TT CAN INDICATE LOW FIBRINOGEN LEVELS, ABNORMAL FIBRINOGEN, OR THE PRESENCE OF SUBSTANCES INHIBITING CLOTTING, SUCH AS HEPARIN. THIS TEST HELPS DIAGNOSE BLEEDING DISORDERS, MONITOR ANTICOAGULANT THERAPY, AND INVESTIGATE EXCESSIVE CLOTTING OR BLEEDING CONDITIONS
Bleeding time (BT) is a clinical test that measures the time it takes for a small cut to stop bleeding. It assesses platelet function, which is crucial for blood clotting. A prolonged BT can indicate platelet disorders like von Willebrand disease or deficiencies in platelet function caused by medications like aspirin. However, BT is not commonly used today due to its variability and the availability of more reliable platelet function tests.
PROTHROMBIN TIME (PT) STUDIES ASSESS YOUR BLOODS CLOTTING ABILITY. IT MEASURES HOW LONG IT TAKES FOR A BLOOD CLOT TO FORM. THIS TEST IS ESSENTIAL FOR DIAGNOSING BLEEDING DISORDERS, MONITORING ANTICOAGULANT THERAPY LIKE WARFARIN, AND EVALUATING LIVER FUNCTION. BY ANALYZING CLOTTING FACTORS, PT HELPS DETERMINE IF YOUR BLOOD CLOTS TOO QUICKLY OR TOO SLOWLY, WHICH CAN INCREASE THE RISK OF BLEEDING OR BLOOD CLOTS.
Clotting time (CT) is a medical test that measures the time it takes for blood to clot. This test helps assess the bodys ability to form blood clots, which are essential for stopping bleeding.Abnormalities in clotting time can indicate various health conditions, including bleeding disorders, liver disease, and certain medications that affect blood clotting.By evaluating clotting time, healthcare providers can diagnose underlying issues and develop appropriate treatment plans.
A COMPLETE BLOOD COUNT (CBC) IS A COMPREHENSIVE BLOOD TEST THAT PROVIDES INFORMATION ABOUT THE CELLS IN YOUR BLOOD. IT MEASURES THE NUMBER OF RED BLOOD CELLS, WHITE BLOOD CELLS, AND PLATELETS, AS WELL AS HEMOGLOBIN (THE PROTEIN THAT CARRIES OXYGEN) AND HEMATOCRIT (THE PERCENTAGE OF RED BLOOD CELLS IN YOUR BLOOD). A CBC IS USED TO DIAGNOSE AND MONITOR A WIDE RANGE OF CONDITIONS, INCLUDING ANEMIA, INFECTIONS, BLEEDING DISORDERS, AND BLOOD CANCERS.
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6 mL whole blood in 2 Blue Top (Sodium Citrate) tubes. Mix thoroughly by inversion. Transport to Lab within 4 hours. If this is not possible, make PPP within 1 hour of collection as follows: Centrifuge sample at 3600 rpm for 15 min. & transfer supernatant to a clean plastic tube. Centrifuge this supernatant again at 3600 rpm for 15 min. & finally transfer the supernatant (PPP) to 1 labelled clean plastic screw capped vial. FREEZE IMMEDIATELY. Ship frozen. Overnight fasting is preferred. Duly filled . It is recommended that patient discontinues Heparin for 1 day and Oral Anticoagulants for 7 days prior to sampling as these drugs may affect test results. Discontinuation should be with prior consent from the treating Physician.
Chromogenic, Immunoturbidimetry, Electromechanical Clot Detection
No special preparation required
