Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes disease, Primary Biliary Cirrhosis and Indian childhood cirrhosis. Urinary copper concentrations are also used to monitor patients on chelation therapy.

10 mL (5 mL min.) aliquot of 24-hour Urine collected in an acid-washed (metal free) container kit available from TrueMedix. Mix thoroughly. Transfer 10 mL aliquot to vial provided in kit. Measure 24 hour total volume and record on vial and test request form. Ship refrigerated or frozen. Use powderless gloves during specimen collection. If Barium containing contrast media has been administered, the specimen should not be collected for 96 hours.

ICPMS

Sample Daily by 6 pm; Report Next day

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If Barium containing contrast media has been administered, the specimen should not be collected for 96 hours.