FISH: ANEUPLOIDY DETECTION, PRODUCTS OF CONCEPTION (POC) USING CHROMOSOMES 13, 18, 21, X & Y

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FISH: ANEUPLOIDY DETECTION, PRODUCTS OF CONCEPTION (POC) USING CHROMOSOMES 13, 18, 21, X & Y

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CHROMOSOMAL ANEUPLOIDY, THE GAIN OR LOSS OF CHROMOSOMES, IS A MAJOR CAUSE OF EARLY FETAL DEMISE. TRISOMY IS THE MOST COMMON TYPE OF CHROMOSOME ABNORMALITY IN SPONTANEOUS ABORTIONS AND HAS BEEN OBSERVED FOR MOST CHROMOSOMES, WITH 13,18,21, X, AND Y BEING THE MOST COMMON. COMMON TRISOMY IS SEEN IN DOWN SYNDROME (TRISOMY 21). OTHER TRISOMIES INCLUDE PATAU SYNDROME (TRISOMY 13) & EDWARDS SYNDROME (TRISOMY 18).

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