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THE T(9;22) IS A BALANCED TRANSLOCATION BETWEEN CHROMOSOMES 9 & 22 LEADING TO FUSION OF BCR & C-ABL GENES AND TO THE TRANSCRIPTION OF LEUKEMIA SPECIFIC BCR-ABL MRNAS. PHILADELPHIA (PH) CHROMOSOME CAUSING THE BCR/ABL FUSION, IS PRESENT IN APPROXIMATELY 95% CASES OF CHRONIC MYELOID LEUKEMIA (CML) AND 25-30% CASES OF ACUTE LYMPHOBLASTIC LEUKEMIA (ALL). DUE TO DEVELOPMENT OF POTENT TYROSINE KINASE INHIBITORS & ANTI-SENSE THERAPIES, PRESENCE OF BCR/ABL TRANSLOCATION IS A FAVORABLE PROGNOSTIC MARKER.
