FISH: FGFR1 (8p12) GENE REARRANGEMENT

MYELOID & LYMPHOID HEMATOLOGICAL MALIGNANCIES WITH EOSINOPHILIA AND ABNORMALITIES OF FIBROBLAST GROWTH FACTOR RECEPTOR-1 (FGFR1) RESULT FROM THE FORMATION OF ABNORMAL FUSION GENES THAT ENCODE CONSTITUTIVELY ACTIVATED TYROSINE KINASES. REARRANGEMENT OF FGFR1 GENE LOCUS LEADS TO MORE THAN 10 FUSED GENES, WHICH CODE FOR FUSION PROTEINS CONTAINING N-TERMINAL DERIVED FROM A PARTNER GENE AND C-TERMINAL OF TYROSINE KINASE DOMAIN FROM THE FGFR1 GENE, WHICH CAUSES CONSTITUTIVE ACTIVATION OF FGFR1. PATIENTS WITH FGFR1 REARRANGEMENT USUALLY INITIATE WITH MYELOPROLIFERATIVE NEOPLASM (MPN) AND UNDERGO THROUGH DIVERSE CLINICAL COURSES SUCH AS LYMPHOBLASTIC LYMPHOMA (LBL), ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) OR ACUTE MYELOID LEUKEMIA (AML).