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MONOSOMY 7 OR DEL(7Q) IS THE MOST COMMON SOMATIC CYTOGENETIC ABNORMALITY IN PERSONS WITH SECONDARY MDS/AML WHO WERE PREVIOUSLY DIAGNOSED WITH AN ACQUIRED BONE MARROW FAILURE. THIS ABERRATION OCCURS IN 8% OF DE NOVO ACUTE MYELOID LEUKEMIA (AML), IN 5-10% OF DE NOVO PATIENTS WITH MYELODYSPLASTIC SYNDROME (MDS), AND APPROXIMATELY 50% OF THERAPY-RELATED MYELOID NEOPLASMS. MYELOID MALIGNANCIES WITH MONOSOMY 7 OR DEL(7Q) RESPOND POORLY TO CHEMOTHERAPY AND ARE ASSOCIATED WITH AN UNFAVORABLE PROGNOSIS.
