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Rs 11,658 Rs 8,700
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GENOMIC AMPLIFICATION OF MYCN GENE IS MOST CONSISTENTLY ASSOCIATED WITH POOR OUTCOME IN NEUROBLASTOMA CASES. THIS PROTO-ONCOGENE IS DETECTED IN APPROXIMATELY 20% OF NEUROBLASTOMA CASES AND A VARIETY OF OTHER SOLID TUMORS INCLUDING 5% MEDULLOBLASTOMA & GLIOBLASTOMA MULTIFORME. MYCN AMPLIFICATION IS LINKED TO UNDIFFERENTIATED PHENOTYPE OF NEUROBLASTOMA AND ASSOCIATED WITH AGGRESSIVE DISEASE WITH POOR PROGNOSIS. DETECTION OF THIS ABERRATION CAN BE USEFUL TO STRATIFY PATIENTS FOR A MORE INTENSIVE THERAPY.
