FISH: NTRK3 GENE REARRANGEMENT ASSAY

NTRK3 GENE IS LOCATED ON CHROMOSOME 15Q25,9 AND TRANSLOCATIONS AFFECTING THIS GENE HAVE BEEN REPORTED IN SEVERAL CANCER TYPES, INCLUDING GLIOBLASTOMAS, PHILADELPHIA CHROMOSOME-LIKE ACUTE LYMPHOBLASTIC LEUKEMIA, CONGENITAL FIBROSARCOMAS, CELLULAR MESOBLASTIC NEPHROMAS, ACUTE MYELOID LEUKEMIA, RADIATION ASSOCIATED THYROID CANCER, SECRETORY BREAST CARCINOMA & MAMMARY ANALOG SECRETORY CARCINOMA OF THE SALIVARY GLAND. NTRK3 POSITIVE PATIENTS CAN BE TREATED WITH NTRK INHIBITORS SUCH AS THE FDA APPROVED DRUGS LAROTRECTINIB OR ENTRECTINIB. THIS IS ASSOCIATED WITH HIGH RESPONSE RATES, REGARDLESS OF NTRK GENE, FUSION PARTNER AND TUMOR TYPE.