FISH: PDGFR BETA (5q33) GENE REARRANGEMENT

PLATELET DERIVED GROWTH FACTOR RECEPTOR BETA (PDGFRB) IS A PART OF A FAMILY OF PROTEINS CALLED RECEPTOR TYROSINE KINASES. COMMONEST MUTATION IN PDGFRB GENE IS THE TRANSLOCATION OF PDGFRB GENE WITH ETV6 GENE FORMING A VARIANT CALLED ETS VARIANT GENE 6. PATIENTS WITH PDGFRB-ETV6 FUSION PRESENT WITH MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA (CLONAL EOSINOPHILIA AS PER WHO) EG. CHRONIC/JUVEILE MYELOMONOCYTIC LEUKEMIA, ATYPICAL CHRONIC MYELOID LEUKEMIA, MYELODYSPLASTIC SYNDROMES, ACUTE MYELOGENOUS/LYMPHOBLASTIC LEUKEMIAS ETC. THESE PATIENTS RESPOND WELL TO IMATINIB THERAPY.