FISH: RET GENE (10q11.2) REARRANGEMENT

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FISH: RET GENE (10q11.2) REARRANGEMENT

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ABNORMALITIES OF RET (REARRANGED DURING TRANSFECTION) PROTO-ONCOGENE ON CHROMOSOME 10Q11 HAS BEEN IDENTIFIED AS THE CAUSATIVE GENETIC ABNORMALITY IN NEOPLASIA SUCH AS PAPILLARY THYROID CARCINOMA (10 TO 20%), MULTIPLE ENDOCRINE NEOPLASIA TYPE II (MEN2), MEDULLARY THYOID CARCINOMA & LUNG ADENOCARCINOMAS (1 TO 2%). PATIENTS WITH RET REARRANGEMENTS BENEFIT FROM RET KINASE INHIBITOR THERAPY. THIS TEST IS SPECIALLY RECOMMENDED IN PATIENTS WITH LUNG ADENOCARCINOMA WHO ARE NEGATIVE FOR EGFR MUTATIONS & ALK REARRANGEMENTS.

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