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TRANSLOCATION T(11;14) IS FOUND IN MOST CASES OF MANTLE CELL LYMPHOMA (MCL) BUT UPTO 30% OF PATIENTS WITH A CHARACTERISTIC MCL LACK THIS TRANSLOCATION. MCL SHOWS A MALE PREDOMINANCE WITH A HIGH INCIDENCE OF DISSEMINATED DISEASE & POOR OUTCOME EVEN WITH INTENSIVE CHEMOTHERAPY. DUE TO THE POOR PROGNOSIS, AN ACCURATE IDENTIFICATION OF MCL IS IMPERATIVE TO INITIATE SPECIFIC INTENSIVE THERAPEUTIC STRATEGIES. THE T(11;14) IS A COMMON CHROMOSOME TRANSLOCATION IN MULTIPLE MYELOMA & PLASMA CELL LEUKEMIA.
