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CLINICAL STUDIES HAVE DEMONSTRATED ASSOCIATION BETWEEN SOME HLA GENOTYPES AND DRUG INDUCED ADVERSE SKIN REACTIONS. PRESENCE OF HLA B*15:02 ALLELE INCREASES THE RISK OF DEVELOPING TOXIC EPIDERMAL NECROLYSIS (TEN) OR STEVENS- JOHNSON SYNDROME (SJS) WHICH IS A MILDER FORM OF TEN. THE FREQUENCY OF THIS ALLELE IS 10-15% IN CHINESE, 2-4% IN SOUTH EAST ASIANS INCLUDING INDIANS AND <1% IN JAPANESE & KOREANS. THIS ALLELE HAS ALSO BEEN ASSOCIATED WITH ADVERSE REACTIONS TO LAMOTRIGENE USED FOR TREATING EPILEPSY AND BIPOLAR DISORDER.
