IGF BINDING PROTEIN-3; IGFBP-3

IGF - binding protein - 3 (IGFBP - 3) is a protein that binds to insulin - like growth factors (IGFs), primarily IGF - 1 and IGF - 2.It plays a crucial role in regulating the bioavailability and activity of these growth factors.IGFBP - 3 extends the half - life of IGFs in the bloodstream and influences their delivery to target tissues.It also has independent functions, such as modulating cell proliferation, differentiation, and apoptosis.IGFBP - 3 levels are regulated by growth hormone and are often used as a marker of growth hormone status.