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IGF - binding protein - 3 (IGFBP - 3) is a protein that binds to insulin - like growth factors (IGFs),
primarily IGF - 1
and IGF - 2.It plays a crucial role in regulating the bioavailability
and activity of these growth factors.IGFBP - 3 extends the half - life of IGFs in the bloodstream
and influences their delivery to target tissues.It also has independent functions,
such as modulating cell proliferation,
differentiation,
and apoptosis.IGFBP - 3 levels are regulated by growth hormone
and are often used as a marker of growth hormone status.
