IMMUNOHISTOCHEMISTRY: LECT2

AMYLOIDOSIS, OFTEN A MULTIORGAN DISEASE IS CHARACTERIZED BY DEPOSITION OF CONGOPHILIC FIBRILLARY MATERIAL WITH THE AFFECTED ORGANS COMPOSED OF RANDOMLY ORIENTED NON- BRANCHING FIBRILS MEASURING ABOUT 7-11 NM IN DIAMETER. AMONG THE COMMONLY PREVALENT SUB- TYPES, AL AMYLOIDOSIS IS DERIVED FROM IMMUNOGLOBULIN LIGHT CHAINS AND AA AMYLOID FROM SERUM AMYLOID A PROTEIN (AA). THE LESS COMMON VARIANTS INCLUDE THOSE DERIVED FROM FIBRINOGEN (AFIB), TRANSTHYRETIN (ATTR), LYSOZYME (ALYS), AND APOLIPOPROTEINS AI OR AII (AAPOAI, AAPOAII).AMYLOID DEPOSITS COMPOSED OF LEUKOCYTE CHEMOTACTIC FACTOR 2 (LECT2) ARE DESCRIBED RECENTLY AND IN SOME SERIES ARE FOUND TO BE THE THIRD MOST COMMON AMYLOID SUBTYPES AFTER AA AND AL AMYLOID. LEUKOCYTE CELL-DERIVED CHEMOTAXIN 2 (LECT2) WAS ORIGINALLY ISOLATED AND CHARACTERIZED FROM CULTURE MEDIA OF PHA-ACTIVATED HUMAN T-CELL LEUKEMIA CELLS AS PART OF STUDIES TO IDENTIFY CHEMOTACTIC FACTORS IMPORTANT IN THE PATHOPHYSIOLOGY OF NEOPLASIA. ALTHOUGH THE ORIGINAL CHARACTERIZ