Increased urine lead excretion rate indicates significant lead exposure. Measurement of urine lead excretion rate before and after chelation therapy has been used as an indicator of lead exposure. An increase in lead excretion rate in the post-chelation specimen of up to 6 times the rate in the pre-chelation specimen is normal. Blood lead is the best clinical correlate of toxicity.

10 mL (5 mL min.) aliquot of 24-hour Urine collected in an acid washed (metal free) container kit available from TrueMedix. Mix thoroughly. Transfer 10 mL aliquot to vial provided in kit. Measure 24 hour total volume and record on vial and test request form. Ship refrigerated or frozen. Use powderless gloves during specimen collection. If Gadolinium or Iodine containing contrast media has been administered, the specimen should not be collected for 96 hours.

ICPMS

Sample Daily by 6 pm; Report Next day

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If Gadolinium or Iodine containing contrast media has been administered, specimen should not be collected for 96 hours.