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THIS TEST IS USEFUL FOR ELUCIDATION OF MITOCHONDRIAL MUTATIONS LINKED TO THE MITOCHONDRIAL DISEASE MELAS. SYMPTOMS TYPICALLY BEGIN IN CHILDHOOD AND MAY INCLUDE MUSCLE WEAKNESS AND PAIN, RECURRENT HEADACHES, LOSS OF APPETITE, VOMITING AND SEIZURES. MOST AFFECTED INDIVIDUALS EXPERIENCE STROKE-LIKE EPISODES BEGINNING BEFORE AGE 40. MELAS CAN BE INHERITED FROM THE MOTHER AS ONLY FEMALES PASS MITOCHONDRIAL DNA TO THEIR CHILDREN. RARELY MELAS CAN RESULT FROM A NEW MUTATION NOT INHERITED FROM THE MOTHER.
