OXCARBAZEPINE METABOLITE

OXCARBAZEPINE (TRILEPTAL) IS AN ANTI-CONVULSANT USED FOR TREATING GENERALIZED TONIC-CLONIC AND PARTIAL SEIZURES. IT CAN BE ADMINISTERED ALONE OR AS AN ADJUNCT TO OTHER ANTI-CONVULSANTS. CLINICALLY SIGNIFICANT EFFECTS OF OXCARBAZEPINE ARE OBSERVED WHEN PLASMA LEVELS OF ITS ACTIVE METABOLITE, 10-OH-CARBAZEPINE, ARE BETWEEN 15 AND 35 UG/ML. TOXIC SYMPTOMS MAY OCCUR WHEN PLASMA LEVELS EXCEED 35 UG/ML. THERAPEUTIC MORNITORING OF OXCARBAZEPINE AND ITS ACTIVE METABOLITE ARE IMPORTANT FOR ACHIEVING PROPER SERUM/PLASMA CONCENTRATION TO INHIBIT EPILEPTIC SEIZURES AND AVOID ADVERSE EFFECTS.