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PREECLAMPSIA (PE) APPEARS TO BE DUE TO THE RELEASE OF ANGIOGENIC FACTORS FROM THE PLACENTA THAT INDUCES ENDOTHELIAL DYSFUNCTION. SERUM LEVELS OF PLGF (PLACENTAL GROWTH FACTOR) ARE ALTERED IN WOMEN WITH PE AND CAN DISCRIMINATE NORMAL PREGNANCY FROM PE EVEN BEFORE CLINICAL SYMPTOMS OCCUR. IN NORMAL PREGNANCY, THE PRO-ANGIOGENIC FACTOR PLGF INCREASES DURING THE FIRST TWO TRIMESTERS AND THEN DECREASES AS PREGNANCY PROGRESSES TO TERM. IN PE, PLGF LEVELS HAVE BEEN FOUND TO BE LOWER THAN IN NORMAL PREGNANCY.
