PML RARA t(15;17)(q22;q12) GENE REARRANGEMENT QUANTITATIVE PCR

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PML RARA t(15;17)(q22;q12) GENE REARRANGEMENT QUANTITATIVE PCR

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VAST MAJORITY OF CASES OF ACUTE PROMYELOCYTIC LEUKEMIA (APL) HAVE A TRANSLOCATION T(15;17)(Q22;Q12-21) WHICH FUSES THE PROMYELOCYTIC GENE (PML) ON CHROMOSOME BAND 15Q22 TO THE RETINOIC ACID RECEPTOR ALPHA (RARA) GENE AT 17Q12-21. THIS ASSAY IS USEFUL FOR MONTORING PATIENTS IN WHICH T(15;17) (Q22;Q12) HAS BEEN DETECTED.

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