SCA-3 (SPINOCEREBELLAR ATAXIA): ATXN3 GENE MUTATION

97 Ratings

Rs 3,375 Rs 2,500

26 % OFF

SCA3 (MACHADO-JOSEPH DISEASE) IS AN AUTOSOMAL DOMINANT ATAXIA BEING ONE OF THE MOST COMMON AMONG MAJORITY OF POPULATIONS. IT IS CLASSIFIED INTO 3 TYPES NAMELY- TYPE I (AMOTROPHIC LATERAL SCLEROSIS-PARKINSONISM-DYSTONIA TYPE); TYPE II (ATAXIC TYPE) & TYPE III (ATAXIC-AMYOTROPHIC TYPE). MEAN AGE OF ONSET OF SCA3 IS 25 YEARS AND PATIENTS HAVE SEVERE DEBILITATION BY 15 YEARS FROM THE AGE OF ONSET IN TYPES I & II. IN SCA 3 THERE IS A CAG TRINUCLEOTIDE REPEAT IN CHROMOSOME 14Q WHICH RESULTS IN ABNORMAL ATAXIN-3 PROTEIN PRODUCTION.

SCA-3 (SPINOCEREBELLAR ATAXIA): ATXN3 GENE MUTATION

Rs 3,375 Rs 2,500

26 % OFF

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