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SM/RNP ANTIBODY IS DETECTED IN PATIENTS WITH MIXED CONNECTIVE TISSUE DISEASE. ANTIBODIES TO SM ARE HIGHLY SPECIFIC FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND WHEN PRESENT ARE CONSIDERED A MARKER ANTIBODY. HOWEVER, THESE ANTIBODIES ARE FOUND IN ONLY 20% OF PATIENTS WITH SLE. RNP ANTIBODIES ARE FOUND IN 45% OF SLE PATIENTS BUT ARE ALSO OBSERVED IN NUMEROUS OTHER DISEASE STATES SUCH AS SJ GRENS SYNDROME, SCLERODERMA AND POLYMYOSITIS. IN SLE, RNP ANTIBODIES HAVE BEEN ASSOCIATED WITH A RELATIVELY BENIGN DISEASE COURSE WITH LOWER INCIDENCE OF RENAL AND CENTRAL NERVOUS SYSTEM INVOLVEMENT.
