170 Ratings
Rs 4,288 Rs 3,200
25 % OFF
CHROMOSOMAL REARRANGEMENTS CAN PRODUCE TUMORIGENIC FUSION GENES. THIS MECHANISM IS SEEN IN 15-25% OF LEUKEMIAS, LYMPHOMAS & SARCOMAS. FUSIONS CAN BE PRODUCED BY TRANSLOCATIONS, INVERSIONS OR DELETIONS. SPECIFIC GENE FUSIONS IN A PATIENTS TUMOR CELLS HAVE AN IMPORTANT BEARING ON THE MANAGEMENT & PROGNOSIS. THIS TRANSLOCATION RESULTS IN THE MLL- AF4 FUSION GENE AND IS ASSOCIATED WITH A POOR OUTCOME. IT IS FOUND IN >80% CASES OF INFANT ALL AND IS THE MOST FREQUENT MLL TRANSLOCATION IN ALL BUT IS RARELY SEEN IN AML.
