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Test Description not updated
4 mL (2 mL min.) Whole blood in 1 Lavender Top (EDTA) tube. Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Real Time PCR
Sample Mon through Sat by 10 am; Report Next day
Detection of TPMT genetic variants by genotyping is recommended prior to commencing the treatment of patients with Thiopurine drugs such as Azathioprine, 6-Mercaptopurine and 6-Thioguanine for Acute Lymphoblastic Leukemia ; autoimmune disorders like Crohns disease ; Rheumatoid arthritis.TPMT is an enzyme which converts these drugs in the body to an active form. Any genetic defect in this enzyme predisposes patients to a heightened risk of drug-induced bone marrow toxicity due to accumulation of unmetabolised drug. Approximately 0.3% of individuals lack TPMT activity while 11% show reduced activity (variants TPMT*2, 3A ; 3C). 89% of people have normal activity (variant TPMT*1).
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Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
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Truemedix Life Sciences Private Limited,Kodigehalli, Thindlu Main Road, Sahakaranagara, Bangalore, Karnataka - 560092
+91 8055554468