Tpmt (thiopurine Methyl Transferase) Genotyping

TPMT genotyping is a genetic test used to assess an individual's risk of adverse drug reactions to thiopurine medications, such as azathioprine and 6-mercaptopurine. These drugs are commonly used to treat autoimmune diseases like Crohn's disease, ulcerative colitis, and leukemia. Variations in the TPMT gene can affect how the body metabolizes these medications, leading to either excessive toxicity or inadequate therapeutic response. TPMT genotyping can help healthcare providers tailor thiopurine therapy to individual patients, reducing the risk of adverse side effects and optimizing treatment outcomes.