VON WILLEBRAND FACTOR COLLAGEN BINDING ACTIVITY (vWF:CB)

VON WILLEBRAND FACTOR PLAYS A KEY ROLE IN PRIMARY & SECONDARY HEMOSTASIS. IN THE LATTER ROLE IT SERVES AS A CARRIER PROTEIN FOR FACTOR VIII. IT IS THE MOST COMMON INHERITED BLEEDING DISORDER CHARACTERIZED BY EASY BRUISING AND PROLONGED BLEEDING FROM MUCOSAL SURFACES. VON WILLEBRAND FACTOR COLLAGEN BINDING ACTIVITY (VWF:CB) IS USED AS SUPPLEMENTAL ASSAY TO FACTOR VIII ACTIVITY, VWF:AG AND VWF:RCO ASSAYS IN TYPING OF VWD. VWF:CB IS A MEASURE OF VWF INTERACTION WITH THE SUBENDOTHELIAL COLLAGEN AND SHOWS PREFERENTIAL SENSITIVITY TO HIGH MOLECULAR WEIGHT MULTIMERS (HMWM). IT HELPS TO DISTINGUISH VWD TYPES 2A & 2B FROM 2M.