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Test Description not updated
50 mL (10 mL min.) aliquot of 24-hour urine. Collect urine with appropriate volume of 50% HCl to maintain pH between 1–2. Do not use concentrated HCl. Record 24 hour volume on test request form and urine container. Ship refrigerated or frozen. Patient should strictly avoid Alpha- Methyldopa, Buspirone, Codeine, Isoproterenol metabolite, Mandelamine, L-dopa, Parcetamol, Metoclopramide, pepper, alcoholic beverages, tea coffee, tobacco and strenuous exercise at least 72 hours before and during specimen collection.
HPLC-EC
Sample Wed Sat by 9 am; Report Fri Tue
This assay is useful as a screening test for the presumptive diagnosis of catecholamine secreting Pheochromocytoma ; Paragangliomas. Metanephrine and Normetanephrine are 3-Methoxy metabolites of Epinephrine and Normetanephrine respectively. These are further metabolized to VMA. This assay may be used as a first order screening test.
*Metanephrine *Normetanephrine
Patient should strictly avoid Alpha- Methyldopa, Buspirone, Codeine, Isoproterenol metabolite, Mandelamine, L-dopa, Parcetamol, Metoclopramide, pepper, alcoholic beverages, tea coffee, tobacco and strenuous exercise at least 72 hours before and during specimen collection.